In this article, we investigate the possible existence of error-detection/correction mechanisms in the genetic machinery by means of a recently proposed coding strategy. On this basis, we numerically code exons, creating binary parity strings and successively we study their dependence structure by means of rigorous statistical methods (moving block bootstrap, and a new entropy-based method). The results show that parity sequences display complex dependence patterns enforcing the hypothesis of the existence of deterministic error-correction mechanisms grounded on this particular parity coding.
23 Jan 2006
Volume: 25 Issue: 1 Pages: 69-81
IEEE engineering in medicine and biology magazine