Significance: Zirconium aminophosphonate nanosheet supported palladium nanoparticles (Pd@ ZPGly), prepared as shown in Equation 1, catalyzed the Suzuki–Miyaura coupling of aryl bromides 2 with phenylboronic acid (3) in a batch-like flow process (eq. 2). A solution of 2 and 3 in ethanol was pumped through columns of K2CO3 and Pd@ ZPGly to give the corresponding biaryls 4 in 96–98% yield.
© Georg Thieme Verlag
1 Jan 2016
Volume: 12 Issue: 01 Pages: 0105-0105