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The aim of this study was to determine the coreceptor tropism by performing genotypic HIV-1 tropism testing in a cohort of patients perinatally infected with HIV-1 and exposed to antiretroviral therapy. Genotypic coreceptor tropism was determined in patients with HIV-1 RNA100 copies/mL using plasma samples (set at a FPR of 20%), according to European guidelines. Out of 55 patients, 50 had an HIV-1 subtype B strain, and mean (SD) age was 18.2 (4.6) years. The median duration of antiretroviral therapy was 13 years (range, 3–23). Thirty-three (60%) patients harbored the R5 virus. At the time of the testing, the median CD4+ T lymphocyte cell count and percentage were 705 cells/mm3 (474–905) and 32.5% in group R5 and 626 cells/mm3 (450–755 …
Taylor & Francis
Publication date: 
1 Feb 2014

Antonio Di Biagio, Andrea Parisini, Bianca Bruzzone, Roberta Prinapori, Marinella Lauriola, Stefania Paolucci, Alessio Signori, Renata Barresi, Giancarlo Icardi, Silvia Calderisi, Genny Meini, Chiara Dentone, Giovanni Cenderello, Michele Guerra, Anna Maccabruni, Stefano Rusconi, Claudio Viscoli

Biblio References: 
Volume: 15 Issue: 1 Pages: 45-50
HIV clinical trials