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Increases in community-acquired infections caused by extended-spectrum-β-lactamase (ESBL)-producing Enterobacteriaceae have important implications for hospital infection control and empirical antibiotic therapy protocols. We developed and validated a tool for identifying patients harboring these organisms at hospital admission. We retrospectively analyzed chart data for 849 adult inpatients. The derivation cohort included 339 patients admitted to a large hospital in Rome during 2008, with (n = 113) or without (n = 226) culture positivity for ESBL-producing Escherichia coli, Klebsiella spp., or Proteus mirabilis within 48 h after admission. Logistic-regression-based prediction scores were calculated based on variables independently associated with the outcome. The model was validated in a second cohort (n = 510) selected with identical criteria in hospitals in Genoa and Turin during 2009. Prediction scores were …
American Society for Microbiology Journals
Publication date: 
1 Jul 2011

Mario Tumbarello, Enrico Maria Trecarichi, Matteo Bassetti, Francesco Giuseppe De Rosa, Teresa Spanu, Eugenia Di Meco, Angela Raffaella Losito, Andrea Parisini, Nicole Pagani, Roberto Cauda

Biblio References: 
Volume: 55 Issue: 7 Pages: 3485-3490
Antimicrobial agents and chemotherapy