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The objective of this study was to assess the achievement of pharmacokinetic/pharmacodynamic (PK/PD) targets of meropenem (MEM) in critically-ill patients with bloodstream infections (BSI) due to Klebsiella pneumoniae-carbapenemase-producing Klebsiella pneumoniae (KPC-Kp) with MEM minimum inhibitory concentrations (MICs) ≥16 mg/L. Nineteen critically-ill patients with KPC-Kp BSI were given combination therapy including MEM, tigecycline, plus colistin or gentamicin (according to susceptibility testing). MEM was administered as an extended 3-hour infusion of 2 g every 8 hours, or adjusted according to renal function. MEM plasma concentrations were determined by high-performance liquid chromatography. PK/PD targets for MEM were defined as T > 40% 1×MIC and T > 40% 4×MIC. Possible synergisms between MEM and coadministered agents were assessed by time-kill assays based on plasma …
Taylor & Francis
Publication date: 
2 Jan 2017

Valerio Del Bono, Daniele Roberto Giacobbe, Anna Marchese, Andrea Parisini, Carmen Fucile, Erika Coppo, Valeria Marini, Antonio Arena, Alexandre Molin, Antonietta Martelli, Angelo Gratarola, Claudio Viscoli, Paolo Pelosi, Francesca Mattioli

Biblio References: 
Volume: 8 Issue: 1 Pages: 66-73