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PurposePatients admitted to intensive care unit (ICU) with Klebsiella pneumoniae infections are characterized by high mortality. The aims of the present study were to investigate the population pharmacokinetics parameters and to assess the probability of target attainment of meropenem in critically ill patients to provide information for more effective regimens.MethodsTwenty-seven consecutive patients were included in the study. Meropenem was administered as 3-h intravenous (i.v.) infusions at doses of 1–2 g every 8 or 12 h. Meropenem plasma concentrations were measured by a high-performance liquid chromatography (HPLC) method, and a population pharmacokinetics analysis was performed using NONMEM software. Meropenem plasma disposition was simulated for extended (3 h; 5 h) or continuous i.v. infusions, and the following parameters …
Springer Berlin Heidelberg
Publication date: 
1 Jul 2016

Francesca Mattioli, Carmen Fucile, Valerio Del Bono, Valeria Marini, Andrea Parisini, Alexandre Molin, Maria Laura Zuccoli, Giulia Milano, Romano Danesi, Anna Marchese, Marialuisa Polillo, Claudio Viscoli, Paolo Pelosi, Antonietta Martelli, Antonello Di Paolo

Biblio References: 
Volume: 72 Issue: 7 Pages: 839-848
European journal of clinical pharmacology