The very high radiation fluences expected at the high-luminosity large hadron collider (LHC) impose new challenges in terms of design of radiation resistant silicon detectors. The choice to use p-type substrates to improve the charge collection efficiency involves an optimization of the strip isolation to interrupt the inversion layer between the n±implants, limiting the breakdown voltage. To this purpose, TCAD modeling and simulation schemes, already developed and validated at typical LHC fluences have to be adapted to take into account effects usually neglected at lower fluences. To better understand in a comprehensive framework, the complex and articulated phenomena related to bulk and surface radiation damage, measurements on test structures and sensors, as well as TCAD simulations related to bulk, surface and interface effects, have been carried out. In particular, we have studied …