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In this article, we present a mathematical framework based on redundant (non-power) representations of integer numbers as a paradigm for the interpretation of genomic information. The core of the approach relies on modelling the degeneracy of the genetic code. The model allows one to explain many features and symmetries of the genetic code and to uncover hidden symmetries. Also, it provides us with new tools for the analysis of genomic sequences. We review briefly three main areas: (i) the Euplotid nuclear code, (ii) the vertebrate mitochondrial code, and (iii) the main coding/decoding strategies used in the three domains of life. In every case, we show how the non-power model is a natural unified framework for describing degeneracy and deriving sound biological hypotheses on protein coding. The approach is rooted on number theory and group theory; nevertheless, we have kept the technical level to a …
The Royal Society Publishing
Publication date: 
13 Mar 2016

Diego Luis Gonzalez, Simone Giannerini, Rodolfo Rosa

Biblio References: 
Volume: 374 Issue: 2063 Pages: 20150062
Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences