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In 1966, only a few months after the complete elucidation of the standard nuclear genetic code (Kay, 2000), the Russian theoretical physicist Yury Borisovich Rumer uncovered the existence of a particular symmetry (Rumer, 1966): when the keto-amino transformation (also known as Rumer’s transformation) is applied to the bases of a codon then the degeneracy of the transformed codon was changed. In particular, if the amino acid associated to the starting codon has degeneracy 4, then the amino acid associated to the transformed codon has degeneracy 1, 2 or 3 (and vice versa).After half a century from this discovery and despite the universality of Rumer’s symmetry, little is known about its origin and its possible biological significance. In this article we show that the Rumer’s symmetry could have originated in an ancestral version of the genetic code, i.e., the pre-early code, and is a natural consequence of the …
Publication date: 
4 Oct 2019

Diego L Gonzalez, Simone Giannerini, Rodolfo Rosa

Biblio References: 
Pages: 104036